Bo-rasaense ba thehile sethala sa ho kopanya lisebelisoa tsa nanosized, kapa "nano-objects," tsa mefuta e fapaneng haholo - inorganic kapa organic - ho etsa meaho e lakatsehang ea 3-D. Leha self-assembly (SA) e sebelitse ka katleho ho hlophisa li-nanomaterials tsa mefuta e mengata, ts'ebetso e bile e ikhethileng haholo, e hlahisa meaho e fapaneng e ipapisitseng le thepa ea mantlha ea thepa. Joalokaha ho tlalehiloe pampiring e phatlalalitsoeng kajeno ho Nature Materials, sethala sa bona se secha sa DNA-programmable nanofabrication se ka sebelisoa ho hlophisa lisebelisoa tse fapaneng tsa 3-D ka mekhoa e tšoanang e behiloeng ho nanoscale (limilione tse likete tsa mitha), moo optical, lik'hemik'hale tse ikhethang. , le thepa e meng e hlaha.
"Le leng la mabaka a ka sehloohong a etsang hore SA e se mokhoa oa boikhethelo bakeng sa lits'ebetso tse sebetsang ke hore ts'ebetso e ts'oanang ea SA e ke ke ea sebelisoa mefuteng e mengata ea lisebelisoa ho theha lihlopha tse tšoanang tsa 3-D tse hlophisitsoeng ho tsoa ho li-nanocomponents tse fapaneng," ho hlalositse sengoli se tsamaisanang le Oleg Gang. , moetapele oa Soft le Bio Nanomaterials Group Setsing sa Functional Nanomaterials (CFN) - US Department of Energy (DOE) Office of Science User Facility at Brookhaven National Laboratory - le moprofesa oa Chemical Engineering le Applied Physics and Materials Science ho Columbia Engineering. "Mona, re theotse ts'ebetso ea SA ho tloha thepa ea thepa ka ho rala liforeimi tse thata tsa polyhedral tsa DNA tse ka kenyelletsang lintho tse fapaneng tsa tlhaho kapa tsa nano, ho kenyeletsoa tšepe, li-semiconductors, esita le liprotheine le li-enzyme."
Bo-rasaense ba ile ba etsa liforeimi tsa maiketsetso tsa DNA ka sebōpeho sa cube, octahedron le tetrahedron. Ka har'a liforeimi ho na le "matsoho" a DNA ao lintho tsa nano feela tse nang le tatellano ea DNA e tlatsetsang li ka tlamang ho tsona. Li-voxels tsena tsa lintho tse bonahalang - ho kopanngoa ha foreimi ea DNA le nano-object - ke mekotla ea ho haha mehaho ea macroscale 3-D e ka etsoang. Liforeimi li hokahana ho sa tsotelehe hore na nano-object e ka hare ke ea mofuta ofe (kapa che) ho latela tatellano e tlatselletsang eo e kentsoeng ka eona lithabeng tsa tsona. Ho itšetlehile ka sebōpeho sa tsona, liforeimi li na le palo e fapaneng ea li-vertices 'me kahoo li theha mehaho e fapaneng ka ho feletseng. Lintho life kapa life tsa nano tse tšoaroang ka har'a liforeimi li nka sebopeho seo se ikhethileng.
Ho bontša mokhoa oa bona oa ho kopanya, bo-ramahlale ba ile ba khetha metallic (khauta) le semiconducting (cadmium selenide) nanoparticles le protheine ea baktheria (streptavidin) e le lintho tse inorganic le organic nano-objects tse tla behoa ka har'a liforeimi tsa DNA. Ntlha ea pele, ba tiisitse botšepehi ba liforeimi tsa DNA le ho thehoa ha li-voxels tsa thepa ka ho nka litšoantšo ka li-microscopes tsa elektronike setsing sa CFN Electron Microscopy Facility le Setsi sa Van Andel, se nang le lisebelisoa tse ngata tse sebetsang ka mocheso oa cryogenic bakeng sa mehlala ea likokoana-hloko. Ka mor'a moo ba ile ba hlahloba mekhoa ea 3-D lattice ho Coherent Hard X-ray Scattering and Complex Materials Scattering beamlines ea National Synchrotron Light Source II (NSLS-II) - e 'ngoe ea DOE Office of Science User Facility ho Brookhaven Lab. Columbia Engineering Bykhovsky Moprofesa oa Chemical Engineering Sanat Kumar le sehlopha sa hae ba ile ba etsa computational modelling e senolang hore meaho e entsoeng ka liteko (e ipapisitseng le lipaterone tsa ho hasana ha x-ray) e ne e le tse tsitsitseng ka ho fetisisa thermodynamically tseo li-voxels tsa thepa li ka li etsang.
"Li-voxels tsena tsa lintho tse bonahalang li re lumella ho qala ho sebelisa mehopolo e nkiloeng ho liathomo (le limolek'hule) le likristale tseo li li etsang, le ho kenya tsebo ena e kholo le database ho litsamaiso tse khahlang tsa nanoscale," ho hlalositse Kumar.
Liithuti tsa sehlopha sa litlokotsebe tsa Columbia li ile tsa bontša kamoo sethala sa kopano se ka sebelisoang ho tsamaisa tlhophiso ea mefuta e 'meli e fapaneng ea thepa e nang le mesebetsi ea lik'hemik'hale le ea mahlo. Ketsahalong e 'ngoe, ba ile ba kopanya li-enzyme tse peli, ba theha lihlopha tsa 3-D tse nang le boima bo phahameng ba ho paka. Le hoja li-enzyme li ile tsa lula li sa fetohe lik'hemik'hale, li bontšitse keketseho e imenneng hane ea ts'ebetso ea enzymatic. "Li-nanoreactors" tsena li ka sebelisoa ho laola karabelo le ho etsa hore ho be le lisebelisoa tse sebetsang ka lik'hemik'hale. Bakeng sa pontšo ea lisebelisoa tsa optical, ba kopanya mebala e 'meli e fapaneng ea matheba a quantum - li-nanocrystals tse nyenyane tse sebelisoang ho etsa lipontšo tsa thelevishene tse nang le mebala e phahameng le khanya. Litšoantšo tse nkiloeng ka microscope ea fluorescence li bontšitse hore lesela le entsoeng le bolokile bohloeki ba mebala ka tlas'a moeli oa diffraction (wavelength) ea leseli; thepa ena e ka lumella ntlafatso e kholo ea tharollo mekhoeng e fapaneng ea ponts'o le theknoloji ea puisano ea optical.
"Re hloka ho nahana bocha hore na lisebelisoa li ka etsoa joang le hore na li sebetsa joang," ho boletse Gang. “Ho ka ’na ha se ke ha hlokahala hore ho hlophisoe lintho bocha; ho paka feela thepa e teng ka mekhoa e mecha ho ka ntlafatsa thepa ea bona. Mohlomong, sethala sa rona e ka ba theknoloji e nolofalletsang 'ho feta tlhahiso ea khatiso ea 3-D' ho laola thepa ka sekala se senyenyane haholo le ka mefuta e mengata ea lisebelisoa le liqapi tse hlophisitsoeng. Ho sebelisa mokhoa o ts'oanang oa ho etsa li-lattice tsa 3-D ho tsoa linthong tse lakatsehang tsa nano tsa lihlopha tse fapaneng tsa lisebelisoa, ho kopanya tseo ho neng ho ka nkoa li sa lumellane, ho ka fetola li-nanomanufacturing.
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Nako ea poso: Jul-04-2022