Bakuli ba lefu la liphio tse sa foleng (CKD) hangata ba na le hyperphosphatemia, 'me hyperphosphatemia ea nako e telele e ka lebisa ho mathata a tebileng a kang hyperparathyroidism ea bobeli, renal osteodystrophy le lefu la pelo. Ho laola maemo a phosphorus ea mali ke karolo ea bohlokoa ea tsamaiso ea bakuli ba CKD, 'me li-binders tsa phosphate ke lithethefatsi tsa motheo bakeng sa phekolo ea hyperphosphatemia. Lilemong tsa morao tjena,lanthanum carbonate, e le mofuta o mocha oa li-non-calcium phosphate binder le non-aluminium phosphate binder, butle-butle li kene sebakeng sa pono sa batho 'me li qalile "tlhōlisano" le li-binders tsa setso tsa phosphate.
"Melemo" le "metsi" ea li-binders tsa setso tsa phosphate
Likopano tsa setso tsa phosphate haholo-holo li kenyelletsa li-binders tsa phosphate tse nang le calcium (tse kang calcium carbonate le calcium acetate) le li-binders tse nang le phosphate tse nang le aluminium (tse kang aluminium hydroxide). Li kopana le phosphates lijong ho theha metsoako e sa qhibilihang, ka hona ho fokotsa ho monya phosphorus ka mpeng.
Li-binders tsa phosphate tse nang le calcium: Theko e tlase le phello e hlakileng ea ho fokotsa phosphorus, empa tšebeliso ea nako e telele e ka lebisa ho hypercalcemia le ho eketsa kotsi ea vascular calcification.
Li-binders tsa phosphorus tse nang le aluminium: Phello e matla ea phokotso ea phosphorus, empa pokello ea aluminium e chefo e ngata 'me e ka baka lefu la masapo le amanang le aluminium,' me ha joale ha e sebelisoe hakaalo.
Lanthanum carbonate: Ho nyoloha ha mocha, ka melemo e hlahelletseng
Lanthanum carbonate ke carbonate ea rare earth metal element lanthanum, e nang le mochine o ikhethang oa ho tlama phosphorus. E lokolla li-ion tsa lanthanum sebakeng se nang le asiti ea tšilo ea lijo 'me e etsa lanthanum phosphate e sa qhibiliheng haholo ka phosphate, kahoo e thibela ho monya ha phosphorus.
Kenyelletso e khuts'oane ea lanthanum carbonate
| Lebitso la sehlahisoa | Lanthanum carbonate |
| Foromo | La2(CO3)3.xH2O |
| Nomoro ea CAS. | 6487-39-4 |
| Boima ba Molek'hule | 457.85 (anhy) |
| Botenya | 2.6 g/cm3 |
| Sebaka se qhibilihang | N/A |
| Ponahalo | Phofo e tšoeu ea kristale |
| Solubility | E qhibiliha ka metsing, e qhibilihang ka mokhoa o itekanetseng ka li-mineral acid tse matla |
| Botsitso | Habonolo hygroscopic |
Ha ho bapisoa le li-binders tsa setso tsa phosphorus, lanthanum carbonate e na le melemo e latelang:
Ha ho na khalsiamo le aluminium, polokeho e phahameng: E qoba kotsi ea hypercalcemia le chefo ea aluminium, haholo-holo ho bakuli ba nang le phekolo ea nako e telele le kotsi ea ho ba le methapo ea mali.
Bokhoni bo matla ba ho tlama phosphorus, phello e kholo ea phokotso ea phosphorus: Lanthanum carbonate e ka tlama phosphorus ka mokhoa o atlehileng sebakeng se pharaletseng sa pH, 'me bokhoni ba eona bo tlamang bo matla ho feta li-binders tsa setso tsa phosphorus.
Litlamorao tse fokolang tsa ka mpeng, ho mamela mokuli hantle: Lanthanum carbonate e latsoeha hantle, e bonolo ho e nka, ha e na ho teneha ho fokolang ka mpeng, 'me bakuli ba na le monyetla oa ho khomarela kalafo ea nako e telele.
Bopaki ba lipatlisiso tsa bongaka: Lanthanum carbonate e sebetsa hantle
Lithuto tse ngata tsa kliniki li netefalitse katleho le polokeho ea lanthanum carbonate ho bakuli ba CKD. Liphuputso li bontšitse hore lanthanum carbonate ha e tlaase kapa e phahametse li-binders tsa setso tsa phosphate ho fokotsa maemo a phosphorus ea mali, 'me e ka laola ka katleho maemo a iPTH le ho ntlafatsa matšoao a metabolism ea masapo. Ho phaella moo, tšireletseho ea phekolo ea nako e telele ka lanthanum carbonate e ntle, 'me ha ho na pokello e hlakileng ea lanthanum le liketso tse chefo tse fumanoeng.
Phekolo ea motho ka mong: Khetha moralo o motle bakeng sa mokuli
Le hoja lanthanum carbonate e na le melemo e mengata, ha e bolele hore e ka nka sebaka ka ho feletseng li-binders tsa setso tsa phosphate. Setlhare se seng le se seng se na le matšoao le li-contraindication, 'me moralo oa kalafo o lokela ho khethoa ka bomong ho latela boemo bo itseng ba mokuli.
Lanthanum carbonate e loketse bakuli ba latelang:
Bakuli ba nang le hypercalcemia kapa kotsi ea hypercalcemia
Bakuli ba nang le vascular calcification kapa kotsi ea vascular calcification
Bakuli ba nang le mamello e fokolang kapa ts'ebetso e fokolang ea li-binders tsa setso tsa phosphate
Li-binder tsa setso tsa phosphate li ntse li ka sebelisoa ho bakuli ba latelang:
Bakuli ba nang le maemo a fokolang a moruo
Bakuli ba alejiki kapa ba sa mamelle lanthanum carbonate
Ho sheba bokamoso: Lanthanum carbonate e na le bokamoso bo khanyang
Ka ho teba ha lipatlisiso tsa bongaka le ho bokella phihlelo ea bongaka, boemo ba lanthanum carbonate kalafo ea hyperphosphatemia ho bakuli ba CKD bo tla tsoela pele ho ntlafala. Nakong e tlang, ho lebeletsoe hore lanthanum carbonate e be setlamo sa pele sa phosphate, se tlisang litaba tse monate ho bakuli ba bangata ba CKD.
Nako ea poso: Mar-25-2025